Formulation and Evaluation of Liposome Moringa Oleifera Seed Oil (Moringa oleifera L.) as Anti-aging
Keywords:
Moringa oleifera seed oil, liposome, anti-aging
Abstract
Moringa oil is a natural vegetable oil obtained from the juice of the ripe kernels of the Moringa tree (Moringa oleifera L). Moringa seeds have an oil content of up to 40%, and have antioxidant activity with vitamin E content reaching 51% but have low stability. The purpose of this study was to find the best formulation as an anti-aging on liposome delivery system with a ratio of phosphatidylcholine soy lechitin and cholesterol. The method used is thin layer hydration (Thin Film Hydration). The results of the observation on the best formula are the 6th formula on organoleptic examination which is milky yellow in color, has a distinctive smell of lecithin and cholesterol and is in the form of a thick suspension, with a pH of 6.0, particle size 83.98nm using a particle size analyzer and entrapment efficiency of 96.8 % using a UV-Vis spectrophotometer.
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References
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[2] Muliyawan, Dewi dan Suriana, Neti. (2013). AZ tentang kosmetik. Jakarta : PT. Elex Media Komputindo
[3] Sari, P.W., berawi, N.K., dan Kerima, N. (2019). Managemen Topikal AntiAging pada Kulit. Medula. 9 (1): 237243
[4] Sharma, B., dan Sharma, A. (2012). Future prospect of nanotechnology indevelopment of antiageing formulations. Int J Pharm Pharm Sci. 4(3):57-66.
[5] Gharsallah K., Rezig L., Msaada K., Chalh A., and Soltani T. (2021). Chemical Compositionand Profile Characterization of Moringa oleifera LSeed Oil. South African Journal of Botany; (137): 475485
[6] Ditjen POM RI. (2020). Farmakope Indonesia. Edition keenam Jakarta : Departemen Kesehatan Republik Indonesia. Page 79.
[7] OhvoRekilä, H., Ramstedt, B., Leppimäki, P., and Slotte, J. P. (2002). Cholesterol interactions with phospholipids in membranes. Progress in lipid research, 41(1), 6697
[8] Samad, A., Sultana, Y., Aqil, M., 2007. Liposomal drug delivery systems : An update review. Current Drug Delivery, Vol.4, p.297305.
[9] Sashi, Kant., Satinder, Kumar., Bharat, Prashar., 2012. A Complete Review On : Liposomes. International Research Journal of Pharmacy.Vol. 3, No 7.
[10] Laouini, A., Maalej, J., Blouza, I.L., Sfar, S., Charcosset, C., and Fessi, H.(2012). Preparation, Characterization and Applications of Liposomes: State of the Art. Journal of Colloid Science and Biotechnology, Vol. 1. Hal:147–68
[11] Bhattacharjeea, A., Dasa, J.B., Deyb,S., Nayak, K.A., Kr.Roy, P., Chakrabartia,S., and M.D.,D.K.S.,R.S., C.P., M.B.(2020). Development and optimization of besifloxacin hydrochloride loaded liposomal gel prepared by thin film hydration method using 32 full factorial design. Colloids and Surfaces A 585:12407.
[12] Anwekar, H., Patel, S., & Singhai, A. K. Liposome as drug carriers. Int. J. Pharm. Life Sci., 2011; 2(7): 94551
[13] Kaplan, A.B. H., Cetin, M., Orgul, D., Hacimufnewlu, A., dan Hekimoglu, S. (2019). Formulation and In Vitro Evaluation of Topical Nanoemulsion based Gels Containing Daidzein. Journal of Drug Delivery Science and Technology (19) : 30263
[14] Popovska, O. An Overview: Methods for Preparation and Characterization of Liposomes as Drug Delivery Systems. International Journal of Pharmaceutical and Phytopharmacological Research, 2014;3(3): 1320\
[15] Triapriani, Y. (2016). Manufacture of nanocellulose from empty palm fruit bunches by acid hydrolysis method. Thesis. Faculty of Math and Science. Lampung University. Page: 2325.
[16] Kaplan, A.B. H., Cetin, M., Orgul, D., Hacimufnewlu, A., dan Hekimoglu, S. (2019). Formulation and In Vitro Evaluation of Topical Nanoemulsion based Gels Containing Daidzein. Journal of Drug Delivery Science and Technology (19) : 30263
[17] Sari, F., Sinaga, K.R., dan Siahaan, D. (2018). Formulation and Evaluation of Red Palm Olein nanoemulsion. Asian J Pharm Clin Res Vol 11 (9): 237 – 240
[18] Pham, Thi Thuy.( 2012). Coloids And Surface B: Biointerface. Liposome And Niosome Preparation Using A Membrane Contractor For Scale-Up. France. 94:15-21
[19] Laouini, A., Maalej, J., Blouza, I.L., Sfar, S., Charcosset, C., and Fessi, H.(2012). Preparation, Characterization and Applications of Liposomes: State of the Art. Journal of Colloid Science and Biotechnology, Vol. 1. Hal:147–68
[20] Yulita Ni Nyoman Tri Sukartiningsih , Hosea Jaya Edy , Jainer Pasca Siampa. (2019). Calliandra (Calliandra surinamensis Benth) Leaf Ethanol Extract Formulation as Antibacterial. Pharmacon, 8 (4) : 806
[21] Mulia, K., Ramadhan, R., Krisanti, E. (2018). Formulation dan Characterization of Nanoemulgel Mangosteen Extract in Virgin Coconut Oil for Topical Formulation. MATEC Web of Conferences 156, 1–7.
[22] Sabrina Bochicchio, Annalisa Dalmoro, Veronica De Simone, Paolo Bertoncin, Gaetano Lamberti and Anna Angela Barba. 2020. Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems. Cosmetics. 7(22) : 2-3
[23] Tapaswi RD. (2008). Liposome as a Potential Drug Delivery System: A review. International Research Journal of Pharmacy. 2013;4:6-12.
[24] Pattni BS, Chupin VV, Torchilin VP. (2015). New developments in liposomal drug delivery. Chemical Reviews.115:10938-10966
[25] Pham, Thi Thuy.( 2012). Coloids And Surface B: Biointerface. Liposome And Niosome Preparation Using A Membrane Contractor For Scale-Up. France. 94:15-21
Published
2022-07-22
How to Cite
Hartini, P. T., Sumaiyah, & Hasibuan, P. A. Z. (2022). Formulation and Evaluation of Liposome Moringa Oleifera Seed Oil (Moringa oleifera L.) as Anti-aging. International Journal of Science, Technology & Management, 3(4), 1179-1183. https://doi.org/10.46729/ijstm.v3i4.546
Section
Articles
