The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats
Keywords:
Dendrophthoe pentandra, hyperglycemic rats and malondialdehyde (MDA).
Abstract
Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
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References
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[22] P. Sitorus, U. Harahap, M. Pandapotan, and T. Barus, ‘Isolation of β-sitosterol from n-hexane extract of Picria fel-terrae Lour. leave and study of its antidiabetic effect in alloxan induced diabetic mice.’, International Journal of PharmTech Research, vol. 6, no. 1, pp. 137–141, 2014.
[23] S. Syahara, U. Harahap, and T. Widyawati, ‘Activity of Muntingia calabura leaves ethanolic extract on glucose and insulin blood levels in streptozotocin-induced rat’, Asian Journal of Pharmaceutical Research and Development, vol. 7, no. 4, pp. 8–11, 2019.
[2] M. F. Lubis, P. A. Z. Hasibuan, H. Syahputra, J. M. Keliat, V. E. Kaban, and R. Astyka, ‘Duku (Lansium domesticum) Leaves Extract Induces Cell Cycle Arrest and Apoptosis of HepG2 Cells via PI3K/Akt Pathways’, Trends in Sciences, vol. 20, no. 2, pp. 6437–6437, 2023.
[3] M. F. Lubis, P. A. Hasibuan, H. Syahputra, and R. Astyka, ‘A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)’, Open Access Macedonian Journal of Medical Sciences, vol. 10, no. F, pp. 57–65, 2022.
[4] E. A. Abdel-Sattar, A. A. Elberry, F. M. Harraz, S. A. Ghareib, A. A. Nagy, and S. A. Gabr, ‘Antihyperglycemic and hypolipidaemic effects of the methanolic extract of Saudi mistletoe (Viscum schimperi Engl.)’, Journal of Advanced Research, vol. 2, no. 2, pp. 171–177, 2011.
[5] S. P. AP and A. Syauqy, ‘Pengaruh Pemberian Pisang Kepok (Musa Paradisiaca Forma Typical) Terhadap Kadar Malondialdehyde (Mda) Tikus Sprague Dawley Pra-Sindrom Metabolik’, Journal of Nutrition College, vol. 4, no. 4, pp. 314–322, 2015.
[6] M. Brownlee, ‘Biochemistry and molecular cell biology of diabetic complications’, Nature, vol. 414, no. 6865, pp. 813–820, 2001.
[7] H. Sari, V. E. Kaban, F. R. Situmorang, and F. Fahdi, ‘UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH’, Jurnal Penelitian Farmasi & Herbal, vol. 2, no. 1, pp. 24–28, 2019.
[8] M. Muhammad, N. Nasri, V. E. Kaban, D. Satria, and H. Cintya, ‘Antibacterial Potential Ethanol Extract of Papaya Leaves (Carica papaya Linn.) Towards Salmonella typhi’, BEST Journal (Biology Education, Sains and Technology), vol. 5, no. 2, pp. 265–270, 2022.
[9] E. E. Ginting, C. F. Sari, L. Leny, P. Parhan, and P. Ginting, ‘ANALISA SENYAWA METABOLIT SEKUNDER DAN PENGARUH PEMBERIAN SERBUK SEMUT JEPANG TERHADAP KADAR KOLESTEROL PADA TIKUS PUTIH JANTAN’, Jurnal Ilmiah Ibnu Sina, vol. 7, no. 1, pp. 56–65, 2022.
[10] N. Nasri, U. Harahap, J. Silalahi, and D. Satria, ‘Antidiarrheal Effect of Lactobacillus fermentum Isolated from Dengke Naniura on Escherichia coli-induced Rats’, Indonesian Journal of Pharmaceutical and Clinical Research, vol. 5, no. 1, Art. no. 1, Apr. 2022, doi: 10.32734/idjpcr.v5i1.6478.
[11] P. Masiello et al., ‘Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide’, Diabetes, vol. 47, no. 2, pp. 224–229, 1998.
[12] U. A. Siti, ‘PENGARUH PEMBERIAN MESENCHYMAL STEM CELL WHARTON’S JELLY TERHADAP KADAR MALONDIALDEHID (MDA) SERUM TIKUS MODEL OSTEOARTRITIS’, Universitas Andalas, 2020.
[13] D. Helianti and Y. Widiastuti, ‘Aktifitas Fisik Berat Menyebabkan Degenerasi Sel Hepatosit melalui Mekanisme Stres Oksidatif’, Jurnal kedokteran Brawijaya, vol. 27, no. 2, pp. 61–65, 2012.
[14] A. Wijaya, L. H. Nurani, and N. Nurkhasa, ‘AKTIVITAS ANTIOKSIDAN SEDIAAN NANOPARTIKEL KITOSAN EKSTRAK ETANOL KELOPAK ROSELA (Hibiscus sabdariffa L) PADA TIKUS HIPERKOLESTEROL: PENGUKURAN KADAR MALONDIALDEHID (MDA)’, Kartika: Jurnal Ilmiah Farmasi, vol. 2, no. 1, pp. 1–6, 2015.
[15] N. E. Fitriani, S. A. Akhmad, and W. Lestariana, ‘Efek Kuersetin Terhadap Kadar Glukosa Darah Puasa Pada Tikus Diabetes Melitus Tipe 2 Yang Diinduksi Dengan Streptozotocin-Nicotinamide’, JKKI: Jurnal Kedokteran dan Kesehatan Indonesia, pp. 103–110, 2014.
[16] C. Surbakti, P. Sitorus, and D. Satria, ‘Effect of Saurauia vulcani Korth. leaves on superoxide dismutase, HbA1c levels and insulin expression in hyperglycemic rats’, Open Access Macedonian Journal of Medical Sciences, vol. 7, no. 22, p. 3741, 2019.
[17] P. Sitorus and D. Satria, ‘Hypoglycemic activity of ethanolic extract of Saurauia vulcani korth’, LEAVES. Asian J. Pharm. Clin. Res, vol. 11, pp. 35–36, 2018.
[18] R. K. Patel, M. M. Patel, M. P. Patel, N. R. Kanzaria, K. R. Vaghela, and N. J. Patel, ‘Hepatoprotective activity of Moringa oleifera Lam. Fruit on isolated rat hepatocytes’, Pharmacogn Mag, vol. 4, pp. 118–123, 2008.
[19] O. O. Daniel, A. O. Adeoye, J. Ojowu, and O. O. Olorunsogo, ‘Inhibition of liver mitochondrial membrane permeability transition pore opening by quercetin and vitamin E in streptozotocin-induced diabetic rats’, Biochemical and biophysical research communications, vol. 504, no. 2, pp. 460–469, 2018.
[20] P. A. Z. HASIBUAN, P. SITORUS, and D. SATRIA, ‘ANTICANCER ACTIVITY OF Β-SITOSTEROL FROM PLECTRANTHUS AMBOINICUS (LOUR. SPRENG.) LEAVES: IN VITRO AND IN SILICO STUDIES’, Asian J Pharm Clin Res, vol. 10, no. 5, pp. 306–308, 2017.
[21] R. Aninditha Rachmah, U. Harahap, and P. A. Z. Hasibuan, ‘Pengaruh ekstrak etanol kulit buah nanas (Ananas comosus (L.) Merr.) terhadap glukosa darah pada mencit hiperglikemia secara in vivo’, Jurnal’Aisyiyah Medika, vol. 2, no. 1, 2018.
[22] P. Sitorus, U. Harahap, M. Pandapotan, and T. Barus, ‘Isolation of β-sitosterol from n-hexane extract of Picria fel-terrae Lour. leave and study of its antidiabetic effect in alloxan induced diabetic mice.’, International Journal of PharmTech Research, vol. 6, no. 1, pp. 137–141, 2014.
[23] S. Syahara, U. Harahap, and T. Widyawati, ‘Activity of Muntingia calabura leaves ethanolic extract on glucose and insulin blood levels in streptozotocin-induced rat’, Asian Journal of Pharmaceutical Research and Development, vol. 7, no. 4, pp. 8–11, 2019.
Published
2023-03-13
How to Cite
Syafitri, A., Yuandani, Y., & Widyawati, T. (2023). The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats. International Journal of Science, Technology & Management, 4(2), 311-316. https://doi.org/10.46729/ijstm.v4i2.758
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Articles
