Phytochemical Screening Of Ethanol Extract Of Temu Kunci (Boesenbergia Rotunda (L.) Mansf) Rhizome Extract And Testing Of Bilirubin Levels In Male White Mice
Abstract
Liver Disease Is A Deadly Disease That Has Attacked Many People. Liver Disease Is A Disease That Occurs As A Result Of An Unhealthy Lifestyle. Usually, The Patient Will Consume Drugs With Chemical Compounds To Overcome The Problem Of This Disease. The Long-Term Use Of Chemical Drugs Will Certainly Cause Side Effects Or, Even Worse, Cause New Diseases. Therefore, The Latest Treatment Methods Must Be Developed To Minimize Side Effects, Namely The Use Of Traditional Medicines. The Purpose Of This Study Was To Determine The Use Of Temu Kunci Rhizome As An Alternative To Reduce Total Bilirubin Levels In Rats As Experimental Animals. This Study Used Rats As Experimental Animals, Which Were Divided Into 6 Test Groups, Namely Group 1 Without Treatment, Group 2 With 0.5% CMC Suspension, Group 3 With 200 Mg Acetylcysteine, Group 4 With 250 Mg/Kg BW Ethanol Extract Of Temukunci, Group 5 Treated With A 500 Mg/Kg BW Dose Of Ethanol Extract Of Temukunci, And Group 6 With A 750 Mg/Kg BW Ethanol Extract Of Temukunci. From The Results Of The Research Conducted, The Ethanol Extract Of Temu Kunci At A Dose Of 750 Mg/Kg BW Was The Best Treatment For Reducing Total Bilirubin Levels In Rats As Experimental Animals.
Downloads
References
N. P. Wintariani and N. M. D. S. Suena, ‘Pengaruh Ekstrak Etanol Daun Ubi Jalar (Ipomoea Batatas Lamk) sebagai Hepatoprotektor terhadap Kadar Bilirubin Total pada Tikus Putih Jantan Galur Wistar’, Jurnal Ilmiah Medicamento, vol. 3, no. 2, 2017.
M. F. Lubis, P. A. Z. Hasibuan, H. Syahputra, J. M. Keliat, V. E. Kaban, and R. Astyka, ‘Duku (Lansium domesticum) Leaves Extract Induces Cell Cycle Arrest and Apoptosis of HepG2 Cells via PI3K/Akt Pathways’, Trends in Sciences, vol. 20, no. 2, pp. 6437–6437, 2023.
Z. Rani, H. M. Nasution, V. E. Kaban, N. Nasri, and N. B. Karo, ‘Antibacterial activity of freshwater lobster (Cherax quadricarinatus) shell chitosan gel preparation against Escherichia coli and Staphylococcus aureus’, Journal of Applied Pharmaceutical Science, 2022.
N. Nasri, V. E. Kaban, K. Gurning, H. D. Syahputra, and D. Satria, ‘Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa’, INSOLOGI: Jurnal Sains dan Teknologi, vol. 1, no. 3, pp. 252–259, 2022.
A. Dalimunthe, D. Pertiwi, M. Muhmmad, V. E. Kaban, N. Nasri, and D. Satria, ‘The effect of extraction methods towards antioxidant activity of ethanol extract of Picria fel-terrae Lour. Herbs’, in IOP Conference Series: Earth and Environmental Science, IOP Publishing, 2022, p. 012040.
R. A. Akmalia, H. Hajrah, and L. Rijai, ‘Aktivitas Antiinflamasi Ekstrak Rimpang Temu Kunci (Boesenbergia pandurata) Secara In-Vitro’, in Proceeding of Mulawarman Pharmaceuticals Conferences, 2016, pp. 289–294.
Y. Farida, T. M. Andayani, and N. Ratnasari, ‘Analisis penggunaan obat pada komplikasi sirosis hati’, Jurnal Manajemen dan Pelayanan Farmasi (Journal of Management and Pharmacy Practice), vol. 4, no. 2, pp. 77–84, 2013.
H. Sari, V. E. Kaban, F. R. Situmorang, and F. Fahdi, ‘UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH’, Jurnal Penelitian Farmasi & Herbal, vol. 2, no. 1, pp. 24–28, 2019.
N. W. Martiningsih and I. A. P. Suryanti, ‘Skrining Fitokimia dan Aktivitas Antijamur Minyak Atsiri Daun Kemangi (Ocimum sp.)’, in Seminar Nasional Riset Inovatif, 2017, pp. 631–636.
S. Yulianto, ‘Identifikasi Alkaloid Daun Kelor (Moringa oleifera L)’, Jurnal Kebidanan dan Kesehatan Tradisional, vol. 5, no. 1, pp. 55–57, 2020.
Y. Noviyanty, H. Hepiyansori, and B. R. Dewi, ‘Identifikasi dan penetapan kadar senyawa saponin ekstrak etanol bunga senggani (Melastoma malabathricum L) metode gravimetri’, Oceana Biomedicina Journal, vol. 3, no. 1, pp. 45–53, 2020.
E. S. Sulasmi, M. Saptasari, K. Mawaddah, and F. A. Zulfia, ‘Tannin identification of 4 species pterydophyta from Baluran National Park’, in Journal of Physics: Conference Series, IOP Publishing, 2019, p. 012002.
S. Arora and P. Itankar, ‘Extraction, isolation and identification of flavonoid from Chenopodium album aerial parts’, Journal of traditional and complementary medicine, vol. 8, no. 4, pp. 476–482, 2018.
E. Mashunah and S. Sitorus, ‘Isolasi dan Identifikasi Steroid dari Ekstrak N-Heksana Daun Afrika (Vernonia amygdalina Del.)’, KOVALEN: Jurnal Riset Kimia, vol. 6, no. 1, pp. 18–22, 2020.
E. Cahyaningsih, P. E. S. K. Yuda, and P. Santoso, ‘Skrining fitokimia dan uji aktivitas antioksidan ekstrak etanol bunga telang (Clitoria ternatea L.) dengan metode spektrofotometri uv-Vis’, Jurnal Ilmiah Medicamento, vol. 5, no. 1, pp. 51–57, 2019.
I. Rubianti, N. Azmin, and M. Nasir, ‘Analisis Skrining Fitokimia Ekstrak Etanol Daun Golka (Ageratum conyziodes) Sebagai Tumbuhan Obat Tradisional Masyarakat Bima’, JUSTER: Jurnal Sains dan Terapan, vol. 1, no. 2, pp. 7–12, 2022.
V. E. Kaban, J. O. Aritonang, Y. C. Hasibuan, and D. I. P. Meliala, ‘EFEKTIVITAS PENYEMBUHAN LUKA SAYAT MENGGUNAKAN SALEP EKSTRAK ETANOL DAUN SENGGANI (Melastoma malabathricum L.) PADA KELINCI’, Jurnal Penelitian Farmasi & Herbal, vol. 2, no. 2, pp. 8–14, 2020.
D. Satria, J. Silalahi, G. Haro, S. Ilyas, and P. A. Z. Hsb, ‘Antioxidant and antiproliferative activities of an ethylacetate fraction of Picria fel-terrae Lour. herbs’, Asian Pacific journal of cancer prevention: APJCP, vol. 18, no. 2, p. 399, 2017.
V. Senthil and D. Sripreethi, ‘Formulation and evaluation of paracetamol suspension from Trigonella foenum graecum mucilage’, Journal of advanced pharmacy education & research, vol. 1, no. 5, pp. 225–233, 2011.
H. D. Syahputra, N. Nasri, and V. E. Kaban, ‘Pengujian Potensi Aktivitas Antibakteri dari Daun Cep-cepan (Saurauia cauliflora DC.) dalam Formulasi Sediaan Gel Terhadap Propionibacterium acnes’, Herbal Medicine Journal, vol. 5, no. 1, pp. 28–32, 2022.
R. F. Goa, A. M. Kopon, and E. G. Boelan, ‘Skrining Fitokimia Senyawa Metabolit Sekunder Ekstrak Kombinasi Kulit Batang Kelor (Moringa oleifera) dan Rimpang Temulawak (Curcuma Xanthorrhiza) Asal Nusa Tenggara Timur’, Jurnal Beta Kimia, vol. 1, no. 1, pp. 37–41, 2021.
M. F. Lubis, H. Syahputra, D. N. Illian, and V. E. Kaban, ‘Antioxidant activity and nephroprotective effect of Lansium parasiticum leaves in doxorubicin-induced rats’, 2022.
U. Harahap, P. A. Z. Hasibuan, P. Sitorus, N. Arfian, and D. Satria, ‘Antimigration activity of an ethylacetate fraction of Zanthoxylum acanthopodium DC. fruits in 4T1 breast cancer cells’, Asian Pacific Journal of Cancer Prevention: APJCP, vol. 19, no. 2, p. 565, 2018.
Y. Wang et al., ‘Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress, inflammation, and apoptosis’, Food & Function, vol. 12, no. 6, pp. 2468–2480, 2021.
V. E. Kaban, J. O. Aritonang, Y. C. Hasibuan, and D. I. P. Meliala, ‘EFEKTIVITAS PENYEMBUHAN LUKA SAYAT MENGGUNAKAN SALEP EKSTRAK ETANOL DAUN SENGGANI (Melastoma malabathricum L.) PADA KELINCI’, Jurnal Penelitian Farmasi & Herbal, vol. 2, no. 2, pp. 8–14, 2020.
U. Harahap, A. Dalimunthe, T. Hertiani, M. Muhammad, Nasri, and D. Satria, ‘Antioxidant and antibacterial activities of ethanol extract of Vernonia amygdalina Delile. Leaves’, in AIP Conference Proceedings, AIP Publishing LLC, 2021, p. 080011.
D. A. Nuari, A. Qowwiyah, and D. Eksyawati, ‘Aktivitas Hepatoprotektor Ekstrak Etanol Rebung Bambu Kuning (Bambusa vulgaris Schard) PADA TIKUS PUTIH JANTAN GALUR WISTAR’, Jurnal Ilmiah Farmako Bahari, vol. 9, no. 2, pp. 16–22, 2019.
A. Shanmugam, K. Kathiresan, and L. Nayak, ‘Preparation, characterization and antibacterial activity of chitosan and phosphorylated chitosan from cuttlebone of Sepia kobiensis (Hoyle, 1885)’, Biotechnology Reports, vol. 9, pp. 25–30, 2016.
